Radiolucent pancreatic lithiasis: a precursor stage for calcified pancreatic lithiasis or a new entity?

OBJECTIVE: Radiolucent pancreatic lithiasis (RPL) has been identified as a different entity from calcified pancreatic lithiasis. The purpose of this study is to evaluate the frequency, characteristics and evolution of RPL. PATIENTS: Between 1983 and 1995, 278 consecutive patients who presented with pancreatic lithiasis were studied. Forty-four patients had RPL (15.8%): 27 had pure radiolucent stones (PRS) (group 1), 5 had pure radiolucent stones combined with evenly calcified stones (ECS) (group 2), 2 had target calculi (TC) (radiolucent core with calcified shell) (group 3), 10 had TC combined with ECS (group 4). RESULTS: Among the 27 patients with PRS, there were 19 males with a mean age of 41 years. PRS were mainly located in the head of the pancreas with a mean diameter of 5 mm (range 3-26 mm). Seven patients among 27 with PRS (26%) were less than 20 years old (juvenile form) or more than 60 years old (senile form). They were characterized by no or low alcohol consumption and a high rate of attacks of acute pancreatitis. In group 1, PRS turned to more advanced calcified stages in 6/16 of patients (37%) followed in 30 to 144 months with a prior stage of TC in 2 cases. An evolution toward more calcified stages (TC or ECS) occurred in half of the patients belonging to group 2 and 4 in 36 to 84 months. Genetic disposition and alcohol consumption could account for the evolution toward more calcified stages. A genetic factor is suggested by a rapid evolution to evenly calcified stones in two aged children 8 and 10 years and by a high frequency of familial cases in patients belonging to groups 2 and 4 (60% and 20%) as compared to group 1 with PRS (4%). Alcohol consumption could accelerate the calcifying process since patients belonging to groups 2 and 4 had a significantly higher alcohol consumption than those with PRS (group 1). CONCLUSION: RPL is a heterogeneous pancreatic disease including juvenile and senile presentation which may represent about 15% of pancreatic lithiasis. Evolution towards calcified stages (PRS then TC then ECS) occurred in 37-50% of cases and could be related to a genetic factor and increased alcohol consumption.

Gallbladder abnormalities in medical ICU patients: an ultrasonographic study.

Patients in the intensive care unit (ICU) have many risks factors for gallbladder stasis or acute acalculous cholecystitis (ACC), including fasting, total parenteral nutrition, sedation, mechanical ventilation, infection and shock. We have performed a prospective study to estimate the prevalence of ultrasonographic gallbladder abnormalities in 30 consecutive medical ICU patients during the first 2 days of their stay in the ICU. Two patients had previously undergone cholecystectomy and were excluded from the study. Seventeen (61%) of the remaining 28 patients presented with gallbladder abnormalities. Considering three major criteria of ACC, 14 patients (50%) presented with either sludge (25%), wall thickening (22%) or hydrops (11%). However, none of the patients needed a surgical procedure during the study because of gallbladder disease. We conclude that an important proportion of ICU patients presented with gallbladder abnormalities shown by ultrasonography and that this may have implications for establishing a diagnosis of ACC using ultrasonographic criteria.

Clinical course and morphological features of chronic calcifying pancreatitis associated with pancreas divisum.

OBJECTIVES: To describe the clinical and radiological patterns of chronic calcifying pancreatitis (CCP) associated with pancreas divisum. DESIGN: Case-control study. METHODS: Pancreas divisum was diagnosed in 20 out of 411 patients presenting with CCP between 1985 and 1994 (group I). They were matched for age and sex with 20 patients presenting with CCP but without pancreas divisum (group II). The cause of CCP was presumed to be mainly chronic alcohol use, as 18 patients in each group had heavy alcohol consumption. RESULTS: The age at onset of the disease was comparable in the two groups (mean 40.8 compared with 42.4 years, NS), and consumption of alcohol and tobacco did not differ. Pancreatic calcified calculi were seen on plain films of the abdomen in eight patients from group I and in 14 patients from group II (P = 0.05). Loss of weight (> 5 kg), diabetes, portal hypertension and the rate of complications of chronic pancreatitis were not significantly different in the two groups. The frequency of attacks of acute pancreatitis was similar (mean 0.9 compared with 1.2 per year, range 0.2-6.0 per year, NS). The occurrence of pseudocysts did not differ (11 compared with 15, NS). Pancreatograms were categorized using the Cambridge classification. No differences could be demonstrated between the two groups (chi 2, P = 0.15). In group I, pancreatographic abnormalities were located only in the ventral segment of the pancreas in three patients, only in the dorsal segment of the pancreas in nine patients and in the whole pancreas in six patients. In two patients, the ventral duct could not be demonstrated. CONCLUSION: We conclude that pancreas divisum does not modify the natural course of CCP. In about one-half of cases, pancreatographic abnormalities may be segmental.